In poultry, how does Campylobacter jejuni colonization relate to CDT compared to humans?

In poultry, how does Campylobacter jejuni colonization relate to CDT compared to humans?

• A. In chickens there are no neutralizing antibodies so CDT does not provoke inflammation.
• B. CDT targets host DNA in poultry, but humans develop neutralizing antibodies and inflammation.
• C. CDT damages chicken bacterial DNA.
• D. CDT is not produced by Campylobacter jejuni in poultry.

Answer: (A)

CDT is a toxin that damages host DNA and can drive inflammation when it acts on host cells. In humans, the immune system can generate neutralizing antibodies against CDT, which can limit the toxin’s activity and the resulting inflammation. In chickens, Campylobacter jejuni colonization is typically asymptomatic, and the avian immune environment does not mount neutralizing antibodies against CDT in the same way as humans. Because the toxin isn’t neutralized in the bird and the avian gut responds differently, CDT activity does not provoke the same inflammatory response seen in humans. This is why poultry can carry Campylobacter without overt disease, making them a reservoir. The other statements conflict with established facts: CDT is produced by C. jejuni in poultry, it targets host DNA (not bacterial DNA), and the notion of not producing CDT in poultry isn’t accurate.

CDT is a toxin that damages host DNA and can drive inflammation when it acts on host cells. In humans, the immune system can generate neutralizing antibodies against CDT, which can limit the toxin’s activity and the resulting inflammation. In chickens, Campylobacter jejuni colonization is typically asymptomatic, and the avian immune environment does not mount neutralizing antibodies against CDT in the same way as humans. Because the toxin isn’t neutralized in the bird and the avian gut responds differently, CDT activity does not provoke the same inflammatory response seen in humans. This is why poultry can carry Campylobacter without overt disease, making them a reservoir. The other statements conflict with established facts: CDT is produced by C. jejuni in poultry, it targets host DNA (not bacterial DNA), and the notion of not producing CDT in poultry isn’t accurate.